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[Prenatal stressed female rats develop stable anxious and depressive state in experimental model of post-traumatic
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|March 7, 2012
Abstract:
The effects of immobilization stress from 15th to 19th days of gestation on pathological state development in the model of post-traumatic stress disorder in adult female offspring were studied. The results showed that prenatally stressed female rats as well as control rats demonstrated long-term high anxiety and hypersensitive glucocorticoid feedback in the stress-restress model. Enhanced depressive-like behaviour was found only in prenatally stressed females. The findings were discussed in the light of HPA axis alteration and risk factors for development of post-traumatic stress disorder.
