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Health behavior change: can genomics improve behavioral adherence?
Colleen M McBride1, Angela D Bryan, Molly S Bray
1National Human Genome Research Institute, Bethesda, MD 20892, USA. cmcbride@mail.nih.gov
American Journal of Public Health
|March 7, 2012
Summary
Genomic information can personalize behavior change interventions by identifying genetic influences on adherence. This approach aims to improve intervention effectiveness by accounting for individual differences.
Area of Science:
- Genomics
- Behavioral Science
- Personalized Medicine
Background:
- Current behavior change interventions show limited effectiveness due to individual variations in adherence.
- The National Human Genome Research Institute highlights genomics for improving behavioral interventions.
Purpose of the Study:
- To explore the potential of using genomic information to customize behavior change interventions.
- To identify adherence macrophenotypes with genetic underpinnings for personalized recommendations.
Main Methods:
- Conducting evidence reviews to find common adherence macrophenotypes with genetic bases.
- Developing conceptual models for biological, psychological, and environmental influences on adherence.
- Collecting biospecimens and adherence data from intervention participants.
Main Results:
- Limited effectiveness of current interventions may stem from ignoring individual adherence variations.
- Genomic data can potentially explain individual differences in response to behavioral interventions.
- Identifying genetic underpinnings of adherence is a crucial first step for customization.
Conclusions:
- Genomic information holds promise for tailoring behavior change interventions to individual needs.
- Further research is needed to understand genetic and environmental factors influencing adherence.
- Systematic collection of biospecimens and adherence data will facilitate intervention customization and effectiveness studies.
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