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Combining Imaging and Electrophysiology to Visualize and Record Spreading Depolarizations in Mice
Published on: October 4, 2024
Propofol hemisuccinate suppresses cortical spreading depression
Ashish Dhir1, Christoph Lossin, Michael A Rogawski
1Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, United States.
Neuroscience Letters
|March 7, 2012
Summary
Propofol hemisuccinate (PHS), a propofol prodrug, effectively inhibited cortical spreading depression (CSD) in mice. This suggests propofol or PHS may be promising treatments for migraine headaches.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Propofol is a sedative-hypnotic anesthetic.
- Migraine headaches may involve cortical spreading depression (CSD).
- Agents inhibiting CSD could treat migraines.
Purpose of the Study:
- To investigate propofol hemisuccinate's (PHS) effect on CSD in mice.
- To compare PHS with dizocilpine, an NMDA receptor antagonist known to inhibit CSD.
Main Methods:
- Intraperitoneal administration of PHS (120 and 200 mg/kg) or dizocilpine (0.5 and 2.5 mg/kg) 15 minutes before KCl-induced CSD in mice.
- Measurement of CSD number, amplitude, and velocity.
- Assessment of PHS for sedative or motor impairment effects.
Main Results:
- PHS (120 and 200 mg/kg) reduced CSD deflections without altering amplitude.
- PHS (200 mg/kg) decreased CSD velocity by 77%.
- Dizocilpine showed comparable CSD inhibition at tested doses. The minimally effective PHS dose did not cause sedation or motor impairment.
Conclusions:
- Acute PHS treatment inhibits CSD in mice.
- Propofol and its prodrug PHS warrant further investigation for migraine treatment.
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