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Proteinuria should be used as a surrogate in CKD
Paolo Cravedi1, Piero Ruggenenti, Giuseppe Remuzzi
1Mario Negri Institute of Pharmacological Research, Azienda Ospedaliera Ospedali Riuniti di Bergamo, Via Stezzano 87, 24126 Bergamo, Italy.
Nature Reviews. Nephrology
|March 7, 2012
Summary
Proteinuria reduction effectively protects kidney function in chronic kidney disease patients. This makes proteinuria a valuable surrogate endpoint for clinical trials evaluating new treatments for proteinuric renal diseases.
Area of Science:
- Nephrology
- Clinical Trials
- Renal Disease Research
Background:
- Chronic kidney disease (CKD) progression involves slow, asymptomatic renal function decline.
- Proteinuria magnitude serves as a key indicator of glomerulopathy severity.
- Population studies link proteinuria to decreased glomerular filtration rate and end-stage renal disease.
Purpose of the Study:
- To establish proteinuria as a reliable surrogate endpoint in clinical trials for proteinuric renal diseases.
- To highlight the significance of proteinuria in predicting CKD progression and treatment efficacy.
Main Methods:
- Analysis of population-based studies correlating proteinuria with renal function decline.
- Evaluation of clinical trial data demonstrating the impact of proteinuria reduction on renal outcomes.
- Assessment of proteinuria as a predictive marker for disease progression and treatment response.
Main Results:
- Proteinuria is a recognized marker for glomerulopathy severity.
- Proteinuria predicts future decline in glomerular filtration rate and end-stage renal disease.
- Reduced proteinuria consistently correlates with preserved renal function in diabetic and nondiabetic renal diseases.
Conclusions:
- Proteinuria is a valuable surrogate endpoint for clinical trials in patients with proteinuric renal diseases.
- Monitoring and reducing proteinuria are crucial for protecting renal function in CKD.
- Proteinuria assessment aids in evaluating the effectiveness of novel therapeutic interventions.
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