Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Face mask sampling for the detection of microbes in expelled aerosols and the impact of airway clearance on microbial yield in children with cystic fibrosis: a feasibility trial.

Journal of medical microbiology·2026
Same author

Are We Ready for the Gift Tongues Can Give to Tuberculosis?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

The Potential Impact of Primary Care-Based Multiplex Polymerase Chain Reaction Point of Care Testing for Viral Acute Respiratory Infections in the UK: Modified Delphi Study.

Health services insights·2025
Same author

Dynamic of infectious aerosols generated by cough from patients with pulmonary tuberculosis.

Journal of aerosol science·2025
Same author

Human Source Severe Acute Respiratory Syndrome Coronavirus 2 Aerosol Transmission to Remote Sentinel Hamsters.

Open forum infectious diseases·2025
Same author

Effect of benralizumab treatment on the airway microbiome in COPD.

ERJ open research·2025

Related Experiment Video

Updated: May 24, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

Targeting persisters for tuberculosis control.

Ying Zhang1, Wing Wai Yew, Michael R Barer

  • 1Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. yzhang@jhsph.edu

Antimicrobial Agents and Chemotherapy
|March 7, 2012
PubMed
Summary

Mycobacterial persisters complicate tuberculosis treatment. Understanding their diverse formation mechanisms and heterogeneity is key to developing novel therapeutic strategies for effective disease control.

Related Experiment Videos

Last Updated: May 24, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Mycobacterial persisters are non-growing survivors of antibiotic treatment, prolonging tuberculosis (TB) therapy.
  • These persister cells represent a major hurdle in TB control due to their complex survival mechanisms.

Purpose of the Study:

  • To explore the heterogeneity and formation pathways of mycobacterial persisters in TB.
  • To identify potential therapeutic strategies for the effective elimination of persister cells.

Main Methods:

  • Review of recent studies on mycobacterial persister formation pathways.
  • Analysis of mechanisms including energy metabolism, stringent response, and toxin-antitoxin systems.

Main Results:

  • Mycobacterial persisters are heterogeneous, with formation influenced by various cellular pathways.
  • Multiple mechanisms contribute to persister formation, such as energy production, stringent response, and efflux pumps.

Conclusions:

  • Targeting persisters through "wake-up" strategies or novel drug combinations is crucial for TB treatment.
  • Personalized treatment regimens considering host genetics and persister levels may improve clinical outcomes.