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Updated: May 24, 2026
High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Development of a robust cytopathic effect-based high-throughput screening assay to identify novel inhibitors of
Kevin D McCormick1, Shufeng Liu, Jana L Jacobs
1Department of Infectious Diseases and Microbiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Abstract:
We have developed a robust cytopathic effect-based high-throughput screening assay to identify inhibitors of dengue virus (DENV) infection. Screening of a small natural product library yielded 11 hits. Four of these were found to be potent inhibitors of DENV, although serotype differences were noted. Taken together, these data suggest that screening of larger and more complex molecule libraries may result in the identification of more potent and specific DENV inhibitors.
