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Economic methods in the century trial--a comprehensive lifestyle modification study for managing coronary artery

James R Langabeer1, Rigoberto Delgado, David Lairson

  • 1Center for Emergency Research, University of Texas School of Public Health, 1200 Herman Pressler Street, RAS-W310, Houston, TX 77030, USA. James.R.Langabeer@uth.tmc.edu

Journal of Cardiovascular Translational Research
|March 7, 2012
PubMed

Insights

The Century Trial investigates the cost-effectiveness of lifestyle changes for coronary artery disease (CAD). This study combines imaging and education to improve patient health and behavior, offering valuable economic insights.

Area of Science:

  • Cardiovascular Medicine
  • Health Economics
  • Preventive Cardiology

Background:

  • Most studies focus on acute coronary conditions, but the Century Trial addresses coronary artery disease (CAD) through lifestyle modification.
  • The Century Trial is a phase III randomized study with 1,300 patients, focusing on preclinical or established CAD.
  • It uniquely combines positron emission tomography imaging with educational and motivational therapy.

Purpose of the Study:

  • To present the economic study design of the Century Trial for reference by other researchers.
  • To detail cost and effect estimation methods, analysis, and uncertainty modeling.
  • To provide evidence on the cost-effectiveness of comprehensive lifestyle modification programs in regressing CAD.

Main Methods:

  • Utilizes positron emission tomography for risk stratification in 1,300 patients.
  • Employs comprehensive educational and motivational therapy for CAD patients.
  • Incorporates quality-adjusted life years and a societal perspective for cost measurement.

Main Results:

  • The study is in its second year of a five-year follow-up.
  • It aims to measure in-trial and lifetime costs using incremental cost-effectiveness ratios.
  • The economic evaluation will assess the value of lifestyle interventions in CAD management.

Conclusions:

  • The Century Trial offers methodological detail for economic evaluations of lifestyle modification programs.
  • It is expected to yield significant evidence on the cost-effectiveness of comprehensive CAD regression strategies.
  • The findings will contribute to understanding the economic benefits of integrating advanced imaging with behavioral interventions.

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