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[Electroanalysis of nifedipine].
1EGIS Gyógyszergyár, Budapest.
Acta Pharmaceutica Hungarica
|July 1, 1990
Summary
Nifedipine can be quantified using electrochemical methods like differential pulse polarography and voltammetry. These techniques detect nifedipine and its degradation products in pharmaceuticals and biological samples.
Area of Science:
- Electrochemistry
- Analytical Chemistry
- Pharmaceutical Analysis
Context:
- Nifedipine is an electrochemically active pharmaceutical.
- Its nitro group's reducibility allows polarographic determination.
- The pyridine ring's saturation influences reduction potential, enabling differentiation.
Purpose:
- Develop differential pulse polarographic (DPP) and voltammetric methods for nifedipine determination.
- Quantify nifedipine and its photolytic degradation products.
- Facilitate pharmacokinetic studies and quality control of pharmaceutical preparations.
Summary:
- Nifedipine's electrochemical activity, specifically the reducibility of its nitro group and oxidizability of its dihydropyridine ring, underpins its analytical determination.
- Differential pulse polarography (DPP) was developed to quantify nifedipine and its aromatic nitro/nitroso photolytic products.
- Selective voltammetric detection and electrochemical (EC) detection in liquid chromatography were achieved due to the 1,4-dihydropyridine group's oxidizability.
Impact:
- Enables accurate quantification of nifedipine in pharmaceutical formulations (tablets, capsules).
- Supports pharmacokinetic studies by determining plasma levels.
- Provides methods for monitoring drug stability and identifying degradation products.