[Bromatometric determination of oxprenolol]

A bromatometric method was elaborated for the quantitative determination of oxprenolol. 15 to 150 mg of oxprenolol dissolved in 10 cm3 of water is brominated by adding 20.00-40.00 cm3 of 0.02 or 0.1 N potassium bromate solution followed by 0.5-3 g of potassium bromide and 1-10 cm3 of 10% w/w hydrochloric acid. After a reaction time of 15 min. 2-10 cm3 of 10% w/w potassium iodide solution is added followed by 20-40 cm3 of chloroform. The liberated iodine is titrated with standard 0.1 N or 0.01 N sodium thiosulphate solution. A blank titration is also performed and the oxprenolol content is calculated from the difference of the two titrations. Under these conditions one oxprenolol molecule reacts with six bromine atoms. The relative standard deviation is 1.31%.