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Updated: May 24, 2026

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation
Zhi-Yong Liu1, Guang-Ling Zhang, Mei-Mei Wang
1Hebei United University Affiliated Hospital, Tang Shan, China.
Abstract:
MicroRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation, and development. In this study, miR-663 was shown to be highly expressed in patients with lung cancer. Furthermore, miR-663 contributed to lung cancer cell proliferation of by regulating TGFB1, P53, Bax, and Fas directly or indirectly. Our results demonstrated that miR-663 plays an important role in the biology of lung cancer and may be useful in developing therapies targeting genes.
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