Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...

Myocarditis I: Introduction

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...

Acute Coronary Syndrome III: Diagnostic Studies

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

Myocarditis III: Medical Management

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacokinetic and pharmacodynamic evaluations of oral moxifloxacin for Enterococcus faecalis endocarditis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026

Same author

Impact of Residual Vegetations After Treatment of Left-Sided Infective Endocarditis: A Substudy of the POET Trial.

JACC. Cardiovascular imaging·2026

Same author

Caregivers' impact in heart failure: a cross-sectional study.

BMJ supportive & palliative care·2025

Same author

Target attainment of benzylpenicillin in patients with infective endocarditis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2025

Same author

Taking a stand, ready or not: navigating sensitive end-of-life care conversations in patients with end-stage heart failure.

European journal of cardiovascular nursing·2025

Same author

Identifying Palliative Care Needs in Patients With Heart Failure Using Patient Reported Outcomes.

Journal of pain and symptom management·2024

Search research articles

Related Experiment Video

Updated: May 24, 2026

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

[Methylphenidate induced ST elevation acute myocardial infarction].

Martin Huth Ruwald¹, Anne-Christine Huth Ruwald, Niels Tønder

¹Kardiologisk Afdeling P, Gentofte Hospital, Niels Andersens Vej 65, 2900 Hellerup, Denmark. mruwald@hotmail.com

Ugeskrift for Laeger

|March 8, 2012

Summary

This summary is machine-generated.

Methylphenidate, used for adult attention deficit and hyperkinetic disorder (ADHD), can cause serious cardiovascular events like myocardial infarction, especially with misuse. Increased caution is advised for at-risk patients.

More Related Videos

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Related Experiment Videos

Last Updated: May 24, 2026

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Area of Science:

Cardiology
Psychiatry
Pharmacology

Background:

Adult attention deficit and hyperkinetic disorder (ADHD) diagnosis and methylphenidate treatment are rising.
Methylphenidate is a central nervous system stimulant commonly prescribed for ADHD.

Observation:

A 20-year-old male with ADHD experienced ST-elevation acute myocardial infarction due to coronary vasospasm.
This event was linked to methylphenidate overdose and subsequent myocardial injury from misuse over two years.

Findings:

Methylphenidate use and misuse can precipitate severe cardiovascular events, including myocardial infarction and injury.
Coronary vasospasm is a potential mechanism for methylphenidate-induced cardiac events.

Implications:

Clinicians should exercise heightened vigilance when prescribing methylphenidate, particularly to patients with a history of substance misuse or pre-existing cardiovascular conditions.
Risk assessment for cardiovascular complications is crucial in patients undergoing methylphenidate therapy for ADHD.
This case highlights the importance of monitoring methylphenidate use to prevent adverse cardiovascular outcomes.