Related Experiment Video
Updated: May 24, 2026

06:40
Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
Published on: October 24, 2025
Has fertility declined in recent decades?
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics & Gynecology, Marmara University School of Medicine, Istanbul, Turkey.
Current Opinion in Obstetrics & Gynecology
|March 8, 2012
Summary
Fertility rates are declining in Europe, influenced by social and behavioral factors. However, projections suggest a future rise in total fertility rates (TFR) to 1.5 or above in many countries.
Area of Science:
- Reproductive Health
- Demography
- Sociology
Background:
- Global concerns exist regarding potential declines in human fertility.
- Numerous studies have investigated fertility trends over the past decade.
- Factors influencing fertility rates are multifaceted, encompassing biological, behavioral, social, and environmental aspects.
Purpose of the Study:
- To review current trends in fertility rates.
- To assess the impact of various factors on fertility.
- To address concerns about a potential decline in human fecundity.
Main Methods:
- Literature review of published studies on fertility trends.
- Analysis of demographic data and projections.
- Examination of biological, behavioral, social, and environmental influences on reproduction.
Main Results:
- The average total fertility rate (TFR) in Europe has fallen to 1.5 children per woman.
- Perceived ideal family size is also decreasing.
- Partnership instability and changing societal values are identified as key factors impacting fertility.
Conclusions:
- Despite current declines and increased use of infertility treatments, a sustained long-term drop in human fecundity appears unsubstantiated.
- Demographic forecasting agencies predict a rise in TFR to 1.5 or higher in most countries.
- The downward trend in fecundity is not supported by current projections, suggesting potential recovery.
Related Concept Videos
Infertility in Males
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...
Menopause
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Conservation of Declining Populations
Conservation of declining population focuses on ways of detecting, diagnosing, and halting a population decline. The approach uses methods to prevent populations from going extinct.
Spermatogenesis
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Oogenesis
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

