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[Optic nerve finding in experimental retinitis induced by herpes simplex virus].
M Yoshioka1, H Ohkuma, M Uyama
1Department of Ophthalmology, Kansai Medical University.
Nippon Ganka Gakkai Zasshi
|August 1, 1990
Summary
Herpes Simplex Virus type 1 (HSV-1) infects the optic nerve via the retina. The virus spreads through nerve fibers to glial cells, causing inflammation and replication.
Area of Science:
- Ophthalmology
- Virology
- Neuroscience
Context:
- Herpes Simplex Virus type 1 (HSV-1) can cause optic nerve disease.
- Understanding HSV-1's intraocular spread is crucial for managing ocular infections.
Purpose:
- To investigate the histological changes and viral localization of HSV-1 within the optic nerve following intravitreal inoculation.
- To elucidate the pathway and cellular tropism of HSV-1 in the optic nerve.
Summary:
- Histological analysis and viral antigen detection revealed no changes at 3 days post-inoculation.
- By day 4, HSV-1 antigens were observed along optic nerve fibers from the lamina cribrosa to the optic chiasma.
- Round cell infiltration increased by day 8, primarily involving oligodendroglia and astrocytes, suggesting viral replication and spread within glial cells.
- Findings indicate HSV-1 infects the optic nerve via the retina and utilizes axonal transport to spread to the brain, infecting glial cells.
Impact:
- This study clarifies the pathogenesis of HSV-1 optic neuropathy.
- Provides insights into viral spread mechanisms within the central nervous system via ocular routes.
- Informs potential therapeutic strategies targeting glial cells or axonal transport in HSV-1 infections.