Related Experiment Videos
[Treatment using CDDP and radiation therapy in treating bladder tumor]
1Department of Urology, Toho University School of Medicine.
Hinyokika Kiyo. Acta Urologica Japonica
|July 1, 1990
Summary
This study explored combination therapy using cis-diamine-dichloroplatinum (CDDP) and radiotherapy for bladder cancer. The treatment showed mild side effects and was effective in preserving the bladder in some patients.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Chemistry
Context:
- Bladder cancer treatment often involves complex therapeutic strategies.
- Combination therapies are increasingly investigated for improved patient outcomes.
- Radiotherapy and chemotherapy play crucial roles in managing various cancer types.
Purpose:
- To evaluate the efficacy and safety of combined cis-diamine-dichloroplatinum (CDDP) and radiotherapy for bladder cancer.
- To assess the impact of this combination therapy on bladder preservation.
- To document the side effects associated with this treatment regimen.
Summary:
- Twenty patients with metastatic epithelial bladder carcinoma (stages T2-T4, grades G2-G3) received combination therapy with CDDP and radiotherapy.
- Twelve patients underwent bladder preservation following transurethral resection (TUR) or TUR biopsy before treatment.
- Observed side effects included anorexia, nausea, vomiting, leukopenia, thrombocytopenia, diarrhea, and skin disorders, all reported as mild and self-limiting.
Impact:
- This combination therapy presents a viable treatment option for bladder cancer, potentially allowing for bladder preservation.
- Understanding the side effect profile aids in patient management and treatment planning.
- The findings contribute to the body of evidence for multimodal approaches in bladder cancer treatment.