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Updated: May 24, 2026

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Synthesis of new trisulfonated calix[4]arenes functionalized at the upper rim, and their complexation with the
Kevin D Daze1, Manuel C F Ma, Florent Pineux
1Department of Chemistry, University of Victoria, P.O. Box 3065, STN CSC, Victoria, BC, Canada.
Abstract:
A synthetic route to produce a new family of trisulfonated calix[4]arenes bearing a single group, selectively introduced, that lines the binding pocket is reported. Ten examples, including new sulfonamide and biphenyl-substituted hosts, each with additional binding elements, demonstrate the tuning of guest affinities and selectivities. NMR titrations in phosphate-buffered water show that one of the new hosts binds to the modified amino acid trimethyllysine with the highest affinity and selectivity observed to date.
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