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Updated: May 24, 2026
Extracellular Vesicle Tissue Factor Activity Assay
Published on: December 29, 2023
Tissue factor and cardiomyocytes
1Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Zentrum für Herz und Kreislaufmedizin, 12200 Berlin, Germany. ursula.rauch@charite.de
Insights
Tissue factor (TF) is crucial for preventing bleeding in organs. This review explores TF
Area of Science:
- Cardiovascular Biology
- Hemostasis and Thrombosis
- Cardiac Pathophysiology
Background:
- Tissue factor (TF) initiates blood coagulation and is constitutively expressed in cardiomyocytes and fibroblasts.
- Beyond hemostasis, TF is implicated in various cardiac functions.
- Understanding TF's role is vital for cardiac health.
Purpose of the Study:
- To review the diverse functions of tissue factor within the heart.
- To emphasize the role of TF in cardiac pathological conditions.
Main Methods:
- Literature review of existing studies on tissue factor in the heart.
- Synthesis of information regarding TF's functions and implications in cardiac disease.
Main Results:
- TF is essential for maintaining cardiac hemostasis.
- TF influences several other critical functions within the cardiac muscle.
- Pathological conditions significantly involve TF activity in the heart.
Conclusions:
- Tissue factor plays a multifaceted role in the heart, extending beyond coagulation.
- Further research into TF's specific functions and pathological involvement is warranted.
Abstract:
Tissue factor, the initiator of blood coagulation, plays a major role in the protection of several organs against bleeding. Cardiomyocytes and fibroblasts constitutively express tissue factor. Besides its role for maintain cardiac hemostasis TF has been suggested to have several other important functions in the cardiac muscle. This review summarizes the different roles of TF in the heart with a special focus on pathological conditions.
