Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unplanned conversion to open in elective laparoscopic and robotic paraesophageal hernia repair: a propensity score matched analysis of the ACS-NSQIP registry.

Surgical endoscopy·2026
Same author

White paper on effective preacquisition evaluation of soft tissue robotic surgery platforms for healthcare institutions.

Surgical endoscopy·2026
Same author

Barbed sutures in ventral hernia repair: A propensity-matched analysis of the Abdominal Core Health Quality Collaborative database.

Surgery·2025
Same author

Validation of the ACS-NSQIP surgical risk calculator for patients with paraoesophageal hernias undergoing robotic repair.

Surgical endoscopy·2025
Same author

Characterizing advanced stapling technique using objective performance indicators in robotic-assisted sleeve gastrectomy: a retrospective cohort study.

Surgical endoscopy·2025
Same author

Longitudinal assessment of disparities in pancreatic cancer care: A retrospective analysis of the National Cancer Database.

World journal of surgery·2024
Same journal

Comment on: Preoperative body mass index reduction and 30-day outcomes after metabolic and bariatric surgery: an MBSAQIP 2015-2023 analysis.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery·2026
Same journal

Perceived changes in alcohol effects after metabolic and bariatric surgery and one-year alcohol-related outcomes: the moderating role of anxiety.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery·2026
Same journal

Comment on: Endoscopic septotomy with argon plasma coagulation (ES-APC) for the management of refractory post-bariatric surgery fistulas and leaks (with video): results from a tertiary referral center.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery·2026
Same journal

Comment on: "Single anastomosis duodeno-ileal bypass with sleeve gastrectomy in the United States: has increased volume impacted safety?"

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery·2026
Same journal

Predictors of 1-year weight maintenance after intragastric balloon removal: a real-world cohort study of 478 patients.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery·2026
Same journal

Late hiatal hernia after Roux-en-Y gastric bypass: a systematic review.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery·2026
See all related articles

Related Experiment Video

Updated: May 24, 2026

One-anastomosis Gastric Bypass (OAGB) in Rats
08:16

One-anastomosis Gastric Bypass (OAGB) in Rats

Published on: November 10, 2018

Abnormal glucose tolerance testing after gastric bypass.

Mitchell S Roslin1, Jonathan H Oren, Barrett N Polan

  • 1Department of Surgery, Lenox Hill Hospital, New York, New York 10075, USA. mroslin@lenoxhill.net

Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery
|March 9, 2012
PubMed
Summary
This summary is machine-generated.

Many Roux-en-Y gastric bypass (RYGB) patients experience abnormal glucose tolerance tests and reactive hypoglycemia. This may contribute to weight regain and eating issues, not prevent them.

More Related Videos

Roux-en-Y Gastric Bypass Operation in Rats
07:37

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

Related Experiment Videos

Last Updated: May 24, 2026

One-anastomosis Gastric Bypass (OAGB) in Rats
08:16

One-anastomosis Gastric Bypass (OAGB) in Rats

Published on: November 10, 2018

Roux-en-Y Gastric Bypass Operation in Rats
07:37

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

Area of Science:

  • Bariatric surgery outcomes
  • Metabolic disorders
  • Endocrinology

Background:

  • Dumping syndrome symptoms are thought to limit carbohydrate intake post-Roux-en-Y gastric bypass (RYGB).
  • Weight regain and post-meal fatigue are common in follow-up RYGB patients.
  • This prompted an investigation into glucose tolerance in post-RYGB individuals.

Purpose of the Study:

  • To assess glucose tolerance test (GTT) results in patients following RYGB.
  • To investigate the prevalence of abnormal glucose metabolism and reactive hypoglycemia after RYGB.

Main Methods:

  • A cohort of 63 RYGB patients, over 6 months post-surgery, underwent GTT and insulin level measurements.
  • Patient data included age, preoperative BMI, excess weight loss, weight regain, and follow-up duration.

Main Results:

  • 49 out of 63 patients exhibited abnormal GTT results.
  • Reactive hypoglycemia was observed in 43 patients (1-2 hours post-glucose load).
  • 6 patients were diabetic preoperatively, with only 1 showing elevated fasting glucose.

Conclusions:

  • Abnormal GTT results are frequent after RYGB.
  • Reactive hypoglycemia is common post-RYGB, and insulin levels do not suggest nesidioblastosis.
  • Hypoglycemia may drive weight regain and maladaptive eating behaviors in some post-RYGB patients.