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Phase transitions in the assembly of multivalent signalling proteins

Pilong Li1, Sudeep Banjade, Hui-Chun Cheng

  • 1Department of Biochemistry and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8812, USA.

Nature
|March 9, 2012
PubMed
Summary

Multivalent macromolecules undergo liquid-liquid phase separation, forming micrometre-sized droplets. This process links molecular changes to macroscopic cell organization and function, particularly in actin regulation.

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