Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of changes in fat metabolism by particulate matter on endometrium and infertility.

Molecular human reproduction·2026
Same author

Particulate matter exposure induces maternal scalp hair loss after birth in C57/B6 mouse via alteration of inflammatory and apoptotic pathways.

Frontiers in endocrinology·2026
Same author

Effects of Exosomes Derived From Eutopic Endometrial Cells in Endometriosis and the Discovery of Related Serum miRNA Biomarkers for Endometriosis.

American journal of reproductive immunology (New York, N.Y. : 1989)·2025
Same author

Effects of chronic particulate matter exposure on endometriosis-associated signaling pathways and disease progression.

Molecular human reproduction·2025
Same author

Investigation of potential toxic effects of nano- and microplastics on human endometrial stromal cells.

Reproductive toxicology (Elmsford, N.Y.)·2025
Same author

Topical Application of Nano-Sized Graphene Oxide Cream Ameliorates Acute Skin Inflammation in Mice.

The Journal of investigative dermatology·2024
Same journal

RETRACTED: Zhang et al. A Novel Framework for Reconstruction and Imaging of Target Scattering Centers via Wide-Angle Incidence in Radar Networks. <i>Sensors</i> 2025, <i>25</i>, 6802.

Sensors (Basel, Switzerland)·2026
Same journal

Enhancing Unsupervised Multi-Source Domain Adaptation for Person Re-Identification via Mixture of Experts and Graph-Based Relation.

Sensors (Basel, Switzerland)·2026
Same journal

Development of an Instrumented Glove for Palmar Pressure Assessment in Kayakers.

Sensors (Basel, Switzerland)·2026
Same journal

Development and Experimental Validation of an Autonomous IoT-Based Monitoring System for Real-Time Water Quality Assessment in the Amazon River.

Sensors (Basel, Switzerland)·2026
Same journal

Semi-Supervised Adversarial Learning Framework for Controller Area Network Bus Intrusion Detection.

Sensors (Basel, Switzerland)·2026
Same journal

Smart Optimization Method for Safety Signs in Innovative Manufacturing Environments Integrating Industrial Field IoT Sensors and Knowledge Graphs.

Sensors (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: May 24, 2026

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes
13:36

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes

Published on: October 20, 2023

Dendritic cells as danger-recognizing biosensors.

Mia Gi1, Wooseok Im, Seokmann Hong

  • 1Department of Bioscience and Biotechnology, College of Life Science, Sejong University, Seoul, 143-747, Korea; E-Mails: gimia@sejong.ac.kr (M.G.); spon13@naver.com (W.I.).

Sensors (Basel, Switzerland)
|March 9, 2012
PubMed
Summary
This summary is machine-generated.

Dendritic cells (DCs) are key antigen-presenting cells that initiate immune responses. Understanding their subsets and functions is crucial for clinical applications in immunology.

Keywords:
Interleukin 12cytokine reporter mouse modeldendritic cellspathogen-associated molecular patternstoll-like receptors

More Related Videos

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Related Experiment Videos

Last Updated: May 24, 2026

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes
13:36

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes

Published on: October 20, 2023

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are critical antigen-presenting cells (APCs) initiating adaptive immunity.
  • DCs possess diverse subsets with unique phenotypes and functions.
  • Innate immune receptors, like Toll-like receptors, trigger DC maturation and antigen presentation.

Purpose of the Study:

  • To review the distinct subsets of dendritic cells (DCs).
  • To elucidate the roles of danger-sensing receptors in DC activation.
  • To discuss the immunological functions of DCs and their clinical relevance.

Main Methods:

  • Review of existing scientific literature on dendritic cells.
  • Discussion of innate immune receptors and their role in DC activation.
  • Introduction of the cytokine reporter mouse model for DC research.

Main Results:

  • DCs are central to initiating immune responses by presenting antigens to T cells.
  • DC subsets exhibit specialized functions in immune polarization.
  • Cytokine reporter mouse models offer insights into DC activation dynamics.

Conclusions:

  • Understanding dendritic cell subsets and their functions is vital for advancing clinical immunology.
  • Targeting DC pathways holds potential for therapeutic immune modulation.
  • Novel models enhance the study of dendritic cell activation and immune responses.