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Updated: May 24, 2026
10:37
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
[Irritable bowel syndrome--irritable bowel or irritable mind?]
Wojciech Marlicz1, Iwona Zawada, Teresa Starzyńska
1Pomeranian Medical University of Szczecin, Poland, Department of Gastroenterology.
Summary
Irritable bowel syndrome (IBS) is a common GI disorder. This review explores IBS causes, focusing on microbiota, and highlights treatments like antibiotics and probiotics targeting the gut-brain axis.
Area of Science:
- Gastroenterology
- Microbiome research
- Neurogastroenterology
Context:
- Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder characterized by abdominal pain, discomfort, and altered bowel habits.
- IBS diagnosis, per Rome Criteria III, increasingly incorporates intestinal transit time for classifying subtypes (diarrhea, constipation, mixed).
- Central nervous system (CNS) comorbidities, including depression and personality disorders, are frequently observed in IBS patients.
Purpose:
- To review current understanding of IBS etiopathogenesis.
- To emphasize the role of the gut microbiota in IBS.
- To describe emerging prophylactic and therapeutic strategies modulating the microbiota and gut-brain axis.
Summary:
- This review synthesizes current knowledge on the causes of IBS, with a particular focus on the gut microbiota's contribution.
- It discusses promising treatments, including antibiotics and probiotics, designed to modulate the gut microbiota and the gut-brain axis.
- Clinical efficacy of the antibiotic rifaximin and the probiotic Lactobacillus plantarum 299v in reducing IBS symptoms is briefly examined.
Impact:
- Provides an overview of IBS pathophysiology, highlighting the gut microbiota's role.
- Discusses novel therapeutic avenues for IBS management.
- Informs clinicians and researchers about evidence-based treatments for IBS symptoms.
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