Related Experiment Video
Updated: May 24, 2026

A Polyaniline-based Sensor of Nucleic Acids
Published on: November 1, 2016
Nanostructured Ag platforms as biosensors of nucleobase chains
Maurizio Muniz-Miranda1, Cristina Gellini, Pier Remigio Salvi
1Department of Chemistry, University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy.
Abstract:
Nanostructured Ag platforms have been obtained by simple chemical procedure and characterized by AFM (atomic force microscopy) measurements, for use in biosensing by means of SERS (surface-enhanced Raman scattering) spectroscopy. The SERS efficiency of these substrates has been verified by microRaman measurements on small RNA chains with different nucleobase content, showing sensitivity near attomole level. It is our opinion that these metal substrates may be widely used as appropriate sensors for detecting biomolecules in many applications concerning medical diagnostics, pharmacological research and nanomaterials technology.
Related Concept Videos
DNA Microarrays
Labeling DNA Probes
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

