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Related Experiment Videos

Experimental canine anaphylaxis: cyclic nucleotides, histamine, and lung function.

S C Lazarus, S E Chesrown, M J Frey

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |May 1, 1979
    PubMed
    Summary

    This study shows that Ascaris suum antigen triggers anaphylaxis in dogs by altering lung cyclic nucleotides and histamine levels. Beta-adrenergic stimulation with isoproterenol can inhibit these anaphylactic responses.

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    Area of Science:

    • Immunology
    • Pharmacology
    • Veterinary Medicine

    Background:

    • Anaphylaxis is a severe allergic reaction with complex biochemical pathways.
    • Understanding the role of cyclic nucleotides and histamine in anaphylaxis is crucial for developing treatments.

    Purpose of the Study:

    • To investigate the in vivo effects of Ascaris suum antigen on lung cyclic nucleotides and histamine in allergic dogs.
    • To explore the potential of beta-adrenergic stimulation to modulate anaphylactic responses.

    Main Methods:

    • 32 natively allergic dogs underwent thoracotomy, vagotomy, and propranolol administration.
    • Peripheral lung samples were analyzed for cyclic nucleotides (cAMP, cGMP) and histamine.
    • Physiological changes of anaphylaxis were monitored.

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  • Beta-adrenergic stimulation with isoproterenol was tested for its inhibitory effects.

    • Main Results:

    • Ascaris suum antigen challenge led to decreased lung histamine and increased cAMP and cGMP levels.
    • Histamine release correlated with anaphylaxis symptoms.
    • Isoproterenol administration inhibited anaphylactic physiological effects.
    • Increased cAMP levels from isoproterenol correlated with reduced histamine release.

    Conclusions:

    • This experimental model effectively demonstrates in vivo anaphylaxis mechanisms.
    • Cyclic nucleotides and histamine play significant roles in allergic reactions.
    • Beta-adrenergic agonists show potential for managing anaphylaxis.