Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Historic malignant tumour: 27 observations].

A Sparsa1, V Doffoel-Hantz, H Durox

  • 1Service de dermatologie et vénéréologie, CHU Dupuytren, 2, avenue Martin-Luther-King, 87042 Limoges, France. antoine.petit@sls.aphp.fr

Annales De Dermatologie Et De Venereologie
|March 10, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of sleep disorders in patients with bullous pemphigoid.

Annales de dermatologie et de venereologie·2026
Same author

Observational study of a series of basal cell carcinomas: Evaluation of location as a risk factor for recurrence.

Journal of stomatology, oral and maxillofacial surgery·2022
Same author

International multicentre observational study to assess the efficacy and safety of a 0·5 mg kg<sup>-1</sup> per day starting dose of oral corticosteroids to treat bullous pemphigoid.

The British journal of dermatology·2021
Same author

Burnout and compassion fatigue among Exercise Physiologists in mental healthcare.

Occupational medicine (Oxford, England)·2020
Same author

Severe adverse events during medical and surgical treatment of hip and knee prosthetic joint infections.

Infectious diseases now·2020
Same author

[An original reconstruction technique for double upper white lip defect].

Annales de dermatologie et de venereologie·2020
Same journal

2024 guidelines (S3) for the therapeutic management of patients with genital herpes.

Annales de dermatologie et de venereologie·2026
Same journal

Topical JAK inhibitors in the lichen planus spectrum: a systematic review.

Annales de dermatologie et de venereologie·2026
Same journal

2024 recommendations for the therapeutic management of anogenital warts.

Annales de dermatologie et de venereologie·2026
Same journal

Depression and anxiety in visible skin diseases affecting the hands and face: a systematic literature review.

Annales de dermatologie et de venereologie·2026
Same journal

HER2 inhibitors in the management of HER2-positive extramammary Paget's disease: a literature review.

Annales de dermatologie et de venereologie·2026
See all related articles

Large, slow-growing malignant tumors, termed "historic" tumors, are often linked to patient psychiatric issues and delayed treatment. These giant tumors present a significant challenge in oncology, impacting patient outcomes.

Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • The term "historic" in French medical literature describes unusually large tumors.
  • Understanding the factors contributing to the extreme growth of these tumors is crucial.

Purpose of the Study:

  • To define the concept of "historic" malignant tumors.
  • To investigate the characteristics and contributing factors of these large cutaneous tumors.

Main Methods:

  • Retrospective analysis of photographs of malignant cutaneous tumors of unusual size (1978-2008).
  • Independent selection by two dermatologists.
  • Collection of socio-professional, demographic, clinical, histological, psychological, and treatment data.

Main Results:

Related Experiment Videos

  • Twenty-seven patients with "historic" tumors (mean age 74) were identified.
  • Average tumor development time was 4.5 years; mean size was 13 cm.
  • Epidermoid carcinomas and melanomas were common; 13 patients had psychiatric issues. Eighteen patients died within 13 months of diagnosis.

Conclusions:

  • "Historic" malignant tumors are a recognized entity, also termed "giant" tumors.
  • Tumor size is associated with slow progression and/or delayed treatment, often due to psychiatric disorders.
  • These tumors affect patients in both urban and rural settings.