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Mouse Oocyte Microinjection, Maturation and Ploidy Assessment
Published on: July 23, 2011
Meiosis: mouse eggs do their anaphase topsy-turvy
1School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan NSW 2308, Australia.
Current Biology : CB
|March 10, 2012
Abstract:
The meiotic separation of sister chromatids in mature metaphase II mouse eggs is observed to depend initially on spindle lengthening (Anaphase B), then on microtubule shortening (Anaphase A). Having Anaphase B precede Anaphase A may be the mechanism by which mammalian eggs can generate a haploid chromosome number but without the loss of too much cytoplasm.
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