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No association between catechol-O-methyltransferase polymorphisms and neurotic disorders among mainland Chinese
Changgui Kou1, Xiangfei Meng, Bing Xie
1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Abstract:
This study investigates the genetic association between catechol-O-methyltransferase (COMT) gene polymorphisms and neurotic disorders. Data were derived from a case-control association study of 255 undergraduates affected by neurotic disorders and 269 matched healthy undergraduate controls. The polymorphisms of eight tag single nucleotide polymorphisms (SNPs) on the COMT gene were tested using polymerase chain reaction (PCR)-based Ligase Detection Reaction (PCR-LDR). The eight tag SNPs on the COMT gene assessed were not associated with neurotic disorders. Our finding suggests that the COMT gene may not be a susceptibility gene for neurotic disorders.
