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Updated: May 24, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
[Gastroesophageal reflux diseases in childhood. Diagnosis and therapy]
1Darmstädter Kinderkliniken Prinzessin Margaret, Dieburgerstr. 31, 64287, Darmstadt, Deutschland. peter.ahrens@kinderkliniken.de
Insights
Diagnosing gastroesophageal reflux diseases linked to airway issues requires multiple tests. Combining procedures like pH monitoring and endoscopy, alongside careful exclusion, aids precise diagnosis, with surgery being key for children.
Area of Science:
- Gastroenterology and Pulmonology
- Diagnostic Medicine
Context:
- Gastroesophageal reflux diseases (GERD) present diagnostic challenges, especially linking pathological reflux to chronic airway conditions.
- No single diagnostic procedure reliably establishes a causal link between GERD and upper/lower airway diseases.
Purpose:
- To outline a diagnostic strategy for identifying GERD-related airway diseases.
- To emphasize the importance of combining multiple diagnostic procedures for accurate diagnosis.
Summary:
- Accurate diagnosis of GERD-related airway diseases involves integrating findings from multi-channel pH monitoring, impedance measurement, video panendoscopy, bronchoalveolar lavage, and lipid-laden alveolar macrophage quantification.
- Differential and exclusion diagnoses are crucial for achieving sufficient diagnostic precision.
- Proton pump inhibitor (PPI) therapy is an initial treatment, with surgical intervention (hemifundoplication) being the preferred method for children.
Impact:
- This multi-modal diagnostic approach improves the precision in identifying GERD as a cause of chronic airway diseases.
- Highlights the critical role of a comprehensive diagnostic workup in managing complex GERD cases.
- Provides a clear treatment pathway, emphasizing surgical intervention for pediatric GERD-related airway conditions.
Abstract:
Gastroesophageal reflux diseases represent a diagnostic challenge, not least since no single diagnostic procedure has been able to establish a causal link between pathological reflux and chronic upper and lower airway diseases. By combining a variety of procedures which point to a link (multi-channel pH measurement, impedance measurement of the esophagus, video panendoscopy, bronchoalveolar lavage, and quantification of lipid-laden alveolar macrophages) and careful differential and exclusion diagnoses, reflux-related diseases can be diagnosed with sufficient precision. In addition to initially successful PPI therapy, surgical intervention (hemifundoplication) is the method of choice in children.
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