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Updated: May 24, 2026

Transuterine Fetal Tracheal Occlusion Model in Mice
Published on: February 5, 2021
[Congenital lung malformations--when to operate?]
1Service de chirurgie pédiatrique viscérale, université Paris-Descartes, hôpital Necker-Enfants-Malades, 149 rue de Sèvres, Paris, France. naziha.khen-dunlop@nck.aphp.fr
Abstract:
Advances in antenatal imaging over the past 10 years have completely changed diagnosis and management of congenital lung disease, especially for congenital cystic adenomatoid malformations and sequestrations that are the two lesions most commonly detected. If early surgical excision is required for symptomatic cases, management of asymptomatic malformations is still discussed. The natural evolution and consequences of later complications of congenital lung malformations need to be compared with the benefits of elective resection and surgical morbidity. Complete regression of sequestrations or clinical and morphological improvement in congenital lobar emphysema pleads for clinical watching. On the other hand, resection is advocated for cystic malformations, because of an increased risk of acute respiratory distress, later infections and the possibility of malignant transformation. Even though the proportion of asymptomatic patients that go on to develop symptoms is hard to evaluate, an argument for elective surgery is a better outcome than emergency surgery. Further studies and long term follow-up are still needed to understand the natural history of congenital lung malformations precisely and help to define the optimal way in which to manage them.
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