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Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State

Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...

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Updated: May 24, 2026

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

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Published on: October 29, 2013

Is hydroxyethyl starch 130/0.4 safe?

Nicolai Haase¹, Anders Perner

¹Department of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

Critical Care (London, England)

|March 13, 2012

Summary

This summary is machine-generated.

Hydroxyethyl starch 130/0.4 (HES) did not show association with kidney injury in septic patients. However, further randomized trials are needed to confirm the safety of HES and assess vasopressor risks.

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Area of Science:

Critical Care Medicine
Nephrology
Pharmacology

Background:

The use of hydroxyethyl starch 130/0.4 (HES) in severe sepsis is debated regarding its nephrotoxic effects.
Observational studies provide preliminary insights but require cautious interpretation for risk identification.

Purpose of the Study:

To evaluate the association between initial resuscitation with HES 130/0.4 and renal impairment in septic patients.
To discuss the implications of observational data on HES safety and the necessity of randomized clinical trials.

Main Methods:

Analysis of a cohort of septic patients receiving initial resuscitation.
Interpretation of observational data regarding HES 130/0.4 administration and renal outcomes.

Main Results:

No association was found between initial HES 130/0.4 resuscitation and renal impairment in the studied septic patient cohort.
Observational data suggested an association between vasopressor use and poor outcomes.

Conclusions:

While the study found no direct link between HES 130/0.4 and renal impairment, its safety cannot be definitively concluded from observational data alone.
Randomized clinical trials are essential to rigorously assess the safety of HES 130/0.4 and other interventions in critically ill patients, particularly concerning vasopressor use.