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Related Experiment Video

Updated: May 24, 2026

Cholesterol Efflux Assay
07:54

Cholesterol Efflux Assay

Published on: March 6, 2012

Crosstalk between reverse cholesterol transport and innate immunity.

Kathleen M Azzam1, Michael B Fessler

  • 1Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

Trends in Endocrinology and Metabolism: TEM
|March 13, 2012
PubMed
Summary

Lipid metabolism and host defense are linked, with cellular sterol levels and innate immunity reciprocally regulating each other. This crosstalk has implications for diseases like atherosclerosis and therapeutic development.

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Area of Science:

  • Biochemistry
  • Immunology
  • Molecular Biology

Background:

  • Lipid metabolism and host defense were traditionally viewed as distinct fields.
  • Emerging evidence indicates shared evolutionary origins and intertwined processes in handling self- and microbe-derived lipids.
  • Lipopolysaccharide (LPS) is a key microbial lipid involved in host-microbe interactions.

Purpose of the Study:

  • To review recent discoveries on the bidirectional crosstalk between reverse cholesterol transport and innate immunity.
  • To explore the implications of this crosstalk for common diseases, particularly atherosclerosis.
  • To highlight potential therapeutic strategies arising from these insights.

Main Methods:

  • Literature review of recent scientific discoveries.
  • Analysis of the interplay between cellular sterol homeostasis and immune responses.
  • Discussion of disease relevance and therapeutic implications.

Main Results:

  • Compelling evidence shows that host cell lipid handling and innate immunity are interconnected.
  • The innate immune response and cellular sterol regulation exhibit reciprocal control.
  • This bidirectional crosstalk is crucial for understanding and potentially treating atherosclerosis.

Conclusions:

  • The separation of lipid metabolism and host defense is artificial; they are inseparable processes.
  • Understanding the crosstalk between reverse cholesterol transport and innate immunity offers new therapeutic avenues.
  • Targeting this interaction could lead to novel treatments for inflammatory and metabolic diseases.