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Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...

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Updated: May 24, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Challenges in development of nanoparticle-based therapeutics.

¹Strategic Platforms, Abraxis BioScience, 11755 Wilshire Blvd., Suite 2300, Los Angeles, California 90025, USA. ndesai@celgene.com

The AAPS Journal

|March 13, 2012

Summary

Nanotechnology offers advanced drug delivery but faces development hurdles. Overcoming manufacturing, safety, and regulatory challenges is key to advancing nanoparticle-based therapeutics.

Area of Science:

Nanomedicine
Drug Development
Biotechnology

Background:

Nanoparticle-based therapeutics show promise for overcoming biological barriers and targeted drug delivery.
Despite advantages, few nanoparticle-based medicines have gained clinical approval due to development challenges.

Purpose of the Study:

To review the challenges in developing and approving nanoparticle-based therapeutics.
To discuss strategies for accelerating the growth of nanomedicines.

Main Methods:

Literature review of nanoparticle-based drug development.
Analysis of challenges in design, manufacturing, safety, and regulation.
Discussion of potential strategies for stakeholders.

Main Results:

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Mechanical Dissociation of Tissues for Single Cell Analysis Using a Motorized Device

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Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Mechanical Dissociation of Tissues for Single Cell Analysis Using a Motorized Device

Mechanical Dissociation of Tissues for Single Cell Analysis Using a Motorized Device

Published on: November 10, 2023

Nanoparticle complexity requires rigorous engineering, analysis, and scale-up.
Safety and efficacy are sensitive to parameter variations, necessitating thorough preclinical and clinical evaluation.
Regulatory standards for nanomedicines are still evolving.

Conclusions:

Addressing manufacturing consistency, safety profiles, and regulatory gaps is crucial for nanomedicine advancement.
Collaboration between developers and regulatory agencies can accelerate the clinical translation of nanoparticle therapeutics.