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Updated: May 24, 2026
08:21
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Dopamine, the kidney, and hypertension.
Raymond C Harris1, Ming-Zhi Zhang
1Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. ray.harris@vanderbilt.edu
Current Hypertension Reports
|March 13, 2012
Summary
Defects in the kidney
Area of Science:
- Nephrology
- Cardiovascular Physiology
- Molecular Biology
Background:
- The intrarenal dopaminergic system regulates blood pressure.
- Dopamine signaling defects contribute to hypertension development.
Purpose of the Study:
- Investigate the role of intrarenal dopamine in salt-sensitive hypertension.
- Examine the link between G-protein receptor kinase 4 (GRK4) and dopamine receptor desensitization in hypertension.
Main Methods:
- Utilized experimental models of salt-sensitive hypertension.
- Analyzed dopamine receptor regulation and GRK4 activity.
- Investigated functional polymorphisms in human cohorts with essential hypertension.
Main Results:
- Abnormalities in intrarenal dopamine production or signaling predispose to salt-sensitive hypertension.
- Increased GRK4 activity leads to dopamine receptor desensitization and AT1 receptor activation.
- Specific GRK4 polymorphisms are associated with essential hypertension.
Conclusions:
- Intrarenal dopamine system dysfunction is implicated in hypertension pathogenesis.
- GRK4 plays a critical role in dopamine receptor desensitization and blood pressure regulation.
- Genetic variations in GRK4 contribute to human essential hypertension.
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