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Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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Related Experiment Video

Updated: May 24, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

EBV-associated lymphomas in adults.

Mark Roschewski¹, Wyndham H Wilson

¹Walter Reed National Military Medical Center, Bethesda, MD 20814, USA. roschewski@mail.nih.gov

Best Practice & Research. Clinical Haematology

|March 14, 2012

Summary

This summary is machine-generated.

Epstein-Barr virus (EBV) causes life-threatening lymphomas in a small subset of infected individuals, particularly those with weakened immunity. Understanding EBV

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Published on: March 30, 2018

Area of Science:

Virology
Immunology
Oncology

Background:

Epstein-Barr virus (EBV), a common γ-herpes virus, infects most of the global population.
While typically latent, EBV can cause severe lymphoproliferative disorders and lymphomas in immunocompromised individuals.
EBV-associated lymphomas are increasingly identified in patients without apparent immunodeficiencies.

Purpose of the Study:

To explore the role of Epstein-Barr virus (EBV) in lymphomagenesis.
To understand the biology of EBV-driven lymphomas.
To identify potential therapeutic targets for EBV-associated malignancies.

Main Methods:

Review of existing literature on EBV biology and associated lymphomas.
Analysis of clinical data from patients with EBV-driven lymphoproliferative disorders.
Investigation into signaling pathways implicated in EBV lymphomagenesis.

Main Results:

EBV can drive uncontrolled lymphocyte proliferation leading to lymphoma.
These lymphomas occur in both overtly and subtly immunocompromised individuals.
Specific signaling pathways are crucial for EBV-driven lymphomagenesis.

Conclusions:

Improved understanding of EBV lymphomagenesis opens avenues for targeted therapies.
Therapeutic strategies may include targeting key signaling pathways.
EBV-specific immunotherapies represent a promising treatment approach.