Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Properties of Organometallic Compounds

Properties of Organometallic Compounds

Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.

Chemical Agents for Microbial Control

Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...

Microbial Corrosion

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...

Metal-Ligand Bonds

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...

Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...

Biological Methods for Microbial Control

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Harnessing Immunogenic PANoptosis With Iridium(III) Biradical Photosensitizers for Melanoma Photoimmunotherapy.

Angewandte Chemie (International ed. in English)·2026

Same author

Emergent cytotoxicity and mitochondrial alterations induced by a heterobimetallic Re(I)/Au(I) complex.

Chemical communications (Cambridge, England)·2026

Same author

Recent Advances in the Use of Osmium Complexes as Anticancer Phototherapeutics.

Accounts of chemical research·2026

Same author

A Deep-Red-Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death.

Angewandte Chemie (International ed. in English)·2026

Same author

Towards a dual copper(II) and iron(III) transmetalation strategy for an anticancer application with the deferasirox chelator.

Journal of inorganic biochemistry·2026

Same author

Correction to "Three in One: <i>In Vitro</i> and <i>In Vivo</i> Evaluation of Anticancer Activity of a Theranostic Agent that Combines Magnetic Resonance Imaging, Optical Bioimaging, and Photodynamic Therapy Capabilities".

ACS applied bio materials·2026

Search research articles

Related Experiment Video

Updated: May 24, 2026

Fabrication of Antibacterial Graphene Oxide/Copper Nanocomposites

Fabrication of Antibacterial Graphene Oxide/Copper Nanocomposites

Published on: October 4, 2024

Small organometallic compounds as antibacterial agents.

Malay Patra¹, Gilles Gasser, Nils Metzler-Nolte

¹Lehrstuhl für Anorganische Chemie I, Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum, Bochum, Germany.

Dalton Transactions (Cambridge, England : 2003)

|March 14, 2012

Summary

Bacterial resistance to antibiotics is a global crisis. New organometallic compounds are emerging as promising antibacterial agents to combat drug-resistant pathogens.

More Related Videos

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

Related Experiment Videos

Last Updated: May 24, 2026

Fabrication of Antibacterial Graphene Oxide/Copper Nanocomposites

Fabrication of Antibacterial Graphene Oxide/Copper Nanocomposites

Published on: October 4, 2024

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

Area of Science:

Medicinal Chemistry
Microbiology
Drug Discovery

Background:

Antibiotic resistance is a major global health concern, driven by increasing pathogen resistance to existing drugs.
The discovery pipeline for new antibacterial agents has slowed, failing to keep pace with resistance.
There is an urgent need for novel therapeutic strategies to control bacterial virulence.

Purpose of the Study:

To review the historical development of organometallic compounds in antibacterial research.
To highlight recent advances in the synthesis of small organometallic compounds as potential antibacterial agents.
To discuss the clinical development potential of these novel compounds.

Main Methods:

Literature review of historical and recent research on organometallic compounds.
Analysis of synthetic methodologies for preparing small organometallic antibacterial agents.
Evaluation of the potential for clinical translation of these compounds.

Main Results:

Organometallic compounds represent a distinct class of molecules with potential antibacterial activity.
Recent synthetic efforts have expanded the library of small organometallic compounds for evaluation.
These compounds show promise for overcoming existing resistance mechanisms.

Conclusions:

Small organometallic compounds offer a promising new avenue for developing antibacterial agents.
Further research and development are warranted to explore their full therapeutic potential.
These agents could provide crucial alternatives in the fight against antibiotic-resistant infections.