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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Carboline alkaloids from Psammosilene tunicoides and their cytotoxic activities
Junmian Tian1, Yunheng Shen, Huiliang Li
1Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
Abstract:
Five new carboline alkaloids, tunicoidines A-E ( 1- 5), and two known carboline alkaloids, 1-acetyl-β-carboline-3-carboxylic acid ( 6) and 1-acetyl-3-carbomethoxyl- β-carboline ( 7), were isolated for the first time from the root of Psammosilene tunicoides. The structures of the new carboline alkaloids were established on the basis of 1D- and 2D-NMR, and HR-MS spectroscopic analyses. The seven compounds were evaluated for cytotoxicity against A549, HCT116, ZR-75-30, and HL-60 cell lines. However, only compound 7 had potent cytotoxic activity against the HCT116 cell line with an IC (50) value of 9.67 µg/mL, while the others showed no cytotoxic activities against the four tested cell lines.
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