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Updated: May 24, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
1-{2-[(4-Chloro-benzyl-idene)amino]phen-yl}-3-phenyl-thio-urea
Peng-Gang Liu1, Xiao-Ning Wang, Yong-An Yang
1State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
Abstract:
The asymmetric unit of the title compound, C(20)H(16)ClN(3)S, contains two independent mol-ecules, A and B. In mol-ecule A, the dihedral angles between the central benzene ring and the pendant chloro-benzene and phenyl rings are 6.37 (15) and 64.79 (15)°, respectively. The corresponding values in mol-ecule B are 28.21 (14) and 82.11 (16)°, respectively. Each mol-ecule features an intra-molecular N-H⋯N hydrogen bond, which generates an S(5) ring. In the crystal, mol-ecules A and B form dimers, being linked by two N-H⋯S hydrogen bonds with graph-set notation R(2) (2)(8).
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