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Updated: May 24, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Mapping gene-environment interactions at regulatory polymorphisms: insights into mechanisms of phenotypic variation
Joseph C Maranville1, Francesca Luca, Matthew Stephens
1Department of Human Genetics, The University of Chicago, Chicago, IL, USA.
Abstract:
Genetic effects on gene regulation make a substantial contribution to phenotypic diversity, yet their mechanisms remain elusive. Here, we discuss the potential insights to be gained from mapping gene-environment interactions at regulatory polymorphisms (i.e., genetic variation that affects gene expression under specific environmental conditions). We highlight a novel statistical method to identify specific patterns of gene-environment interaction at these regulatory polymorphisms. Reviewing its application to a study that mapped gene expression in the presence and absence of glucocorticoids, we discuss the mechanistic insights that this approach provides.
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