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Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...

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Updated: May 24, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

Isolated left ventricular noncompaction: what do we really know?

Ferande Peters1, Bijoy K Khandheria

  • 1Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Bertsham 2013, Johannesburg, South Africa. ferande.peters@gmail.com

Current Cardiology Reports
|March 15, 2012
PubMed
Summary
This summary is machine-generated.

Isolated left ventricular noncompaction (ILVNC) is a genetic cardiomyopathy linked to embryogenesis errors. This review discusses its genetic basis, diagnosis, and management challenges for clinicians.

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Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
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Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

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Last Updated: May 24, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

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Published on: April 8, 2013

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

Area of Science:

  • Cardiology
  • Genetics
  • Developmental Biology

Background:

  • Isolated left ventricular noncompaction (ILVNC) is a rare myocardial disorder.
  • It is now classified as a genetic cardiomyopathy, with both familial and sporadic forms.
  • Genetic heterogeneity exists, with sarcomeric mutations being most common.

Purpose of the Study:

  • To provide clinicians with insights into the complex aspects of ILVNC.
  • To offer practical guidance for managing challenging clinical scenarios related to ILVNC.
  • To highlight areas requiring future research, including familial screening and diagnostic differentiation.

Main Methods:

  • This is a review article, synthesizing current knowledge on ILVNC.
  • It discusses pathogenesis, genetic basis, diagnostic challenges, and management strategies.
  • Literature review and clinical experience are implicitly used.

Main Results:

  • ILVNC arises from an arrest in cardiac embryogenesis.
  • Sarcomeric mutations are the predominant genetic cause in familial ILVNC.
  • Significant controversies and diagnostic challenges remain regarding ILVNC.

Conclusions:

  • ILVNC presents complex diagnostic and management issues.
  • Further research is crucial for understanding familial screening and differentiating ILVNC from normal variants.
  • Clinicians require updated guidance for effective patient care.