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Updated: May 24, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
[The laboratory diagnostic of pancreatitis of Yersinia etiology]
Abstract:
The effectiveness of diagnostic techniques detecting pancreatitis of Yersinia etiology is discussed. The agglutination reaction and immune-enzyme assay have been applied to detect the outer membrane proteins antibodies of various classes coded by plasmid of Yersinia virulence pYV. The polymerase chain reaction technique was applied to detect sites of chromosomal genes coding the factors of Yersinia virulence--superantigen toxin YPM Y. pseudotuberculosis and protein of adhesion/invasion of Ail Y. enterocolitica. The application of the complex of specific techniques of laboratory examination of patients with acute pancreatitis and chronic pancreatitis with exacerbations permitted to confirm the Yersinia etiology of disease in 23.7% of cases. Then serologic techniques are the most informative in laboratory diagnostics.
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Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Assessment:

