[Rational control analysis within the scope of a methadone program]

To effectively control a methadone maintenance program a GC-MS-method was developed to simultaneously assay methadone, the opiates including monoacetylmorphine, cocaine and methaqualone. The automation of the GC-MS-analysis including the evaluation made possible by suitable operators renders possible a procedure, which is cheaper than the corresponding immunoassays while allowing to differentiate between the opiates without the second step.