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Autoantibodies specific for the 20-KDal ribosomal large subunit protein L12
T Sato1, T Uchiumi, R Kominami
1Department of Medicine (II), Niigata University School of Medicine, Japan.
Biochemical and Biophysical Research Communications
|October 30, 1990
Abstract:
New antibodies reactive with a 20 KDal ribosomal protein of the large subunit were found in sera from two of eighty patients with systemic lupus erythematosus. This antigenic protein was identified as L12 by the mobility in two-dimensional gel electrophoresis. Both sera also contained anti-P activity against three acidic phosphoproteins (P proteins), but this activity was completely inhibited by preincubation with the isolated P proteins. Therefore, these anti-L12 can be useful for studying the function of L12 in protein synthesis.