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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Related Experiment Video

Updated: May 24, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Ewing sarcoma/peripheral primitive neuroectodermal tumor and related tumors.

Maria Tsokos¹, Rita D Alaggio, Louis P Dehner

¹Department of Pathology, National Institutes of Health, Bethesda, MD, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

|March 17, 2012

Summary

Ewing sarcoma/peripheral primitive neuroectodermal tumor (EWS/pPNET) and related neoplasms present diagnostic challenges due to overlapping features. This review covers clinicopathologic aspects of EWS/pPNET and desmoplastic small round cell tumors.

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Area of Science:

Oncology
Pathology
Genetics

Background:

Ewing sarcoma/peripheral primitive neuroectodermal tumor (EWS/pPNET) and other EWS gene rearrangement tumors are malignant neoplasms affecting soft tissues in young individuals.
Ewing sarcoma is the third most common pediatric sarcoma.
Desmoplastic small round cell tumor is a rare neoplasm typically affecting older children and young adults.

Purpose of the Study:

To review the clinicopathologic features of EWS/pPNET and desmoplastic small round cell tumor.
To discuss these tumors within the spectrum of neoplasms characterized by EWS gene rearrangements.

Main Methods:

Pathologic examination.
Immunohistochemistry.
Cytogenetics and molecular genetics.

Main Results:

EWS/pPNET and related tumors exhibit overlapping histologic, immunohistochemical, and genetic features, posing diagnostic challenges.
Despite overlapping features, significant clinical and prognostic differences exist between these tumor types.

Conclusions:

Accurate diagnosis of EWS gene rearrangement tumors requires integrated clinicopathologic, immunohistochemical, and molecular genetic analysis.
Understanding the spectrum of EWS gene rearrangement tumors is crucial for appropriate patient management.