Related Experiment Video
Updated: May 24, 2026

Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
Published on: June 2, 2023
A local view of cancer
Ross L Cagan1, Julio A Aguirre-Ghiso
1Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA. ross.cagan@mssm.edu
Abstract:
Research on solid tumors has had limited emphasis on interactions between transformed cells and their neighbors within the epithelium. Leung and Brugge (2012) use cultured breast cancer acini to demonstrate the importance of local interactions between normal and transformed epithelial cells, with important implications for our understanding of epithelial cancers.
Related Concept Videos
What is Cancer?
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer
Cancers Originate from Somatic Mutations in a Single Cell
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

