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Related Experiment Video

Updated: May 24, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Gastrointestinal bleeding and possible hypothyroidism.

Leisa L Marshall¹

¹Mercer University College of Pharmacy and Health Sciences, Atlanta, Georgia 30341, USA. Mashall_L@mercer.edu

The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists

|March 17, 2012

Summary

This summary is machine-generated.

An elderly woman experienced gastrointestinal bleeding from NSAIDs and developed atrial fibrillation (AF). Amiodarone treatment for AF led to thyroid dysfunction, highlighting medication risks in older adults.

Related Experiment Videos

Last Updated: May 24, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Area of Science:

Geriatric Medicine
Pharmacology
Cardiology

Background:

An 88-year-old female with knee arthritis and a shoulder fracture used over-the-counter naproxen sodium for pain.
This NSAID use led to severe duodenal and gastric ulcers, resulting in hospitalization and blood transfusions.

Observation:

During hospitalization for gastrointestinal bleeding, the patient developed new-onset atrial fibrillation (AF).
Due to active bleeding, warfarin was contraindicated for stroke prevention; amiodarone was initiated for rate and rhythm control.
Amiodarone therapy, continued in a nursing facility, was associated with subsequent development of hypothyroidism, indicated by elevated thyroid-stimulating hormone levels.

Findings:

Nonsteroidal anti-inflammatory drug (NSAID) use can precipitate serious gastrointestinal complications, including bleeding and anemia.
Amiodarone, a common antiarrhythmic, can cause thyroid dysfunction (hypothyroidism in this case) as a significant adverse effect.
Managing co-existing conditions and medication side effects in the elderly requires careful consideration of drug interactions and patient-specific risks.

Implications:

This case underscores the importance of vigilant monitoring for adverse drug events, particularly in elderly patients with multiple comorbidities and polypharmacy.
Healthcare providers should weigh the risks and benefits of NSAIDs and antiarrhythmic agents like amiodarone in older adults.
Early detection and management of drug-induced complications, such as GI bleeding and thyroid dysfunction, are crucial for patient outcomes.