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Dipalmitoylphosphatidylcholine (L-alpha-lecithin) stimulates prostaglandin E production in human amnion
T Ohtsuka1, H C Lee, M Yamaguchi
1Department of Obstetrics and Gynecology, Miyazaki Medical College, Japan.
British Journal of Obstetrics and Gynaecology
|September 1, 1990
Abstract:
The effect of dipalmitoylphosphatidylcholine (DPPC, L-alpha-lecithin), a substance not containing arachidonic acid, on prostaglandin E (PGE) production of amniotic membrane was studied. DPPC (3.125-800 micrograms/ml) stimulated PGE production of amniotic membrane (150-200%), suggesting that lecithin, the major surfactant component, is directly involved in the mechanism of human parturition as a stimulator of PGE production.