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Related Experiment Video

Updated: May 24, 2026

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
08:31

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

Single-nanoparticle detection using a low-aspect-ratio pore.

Makusu Tsutsui1, Sadato Hongo, Yuhui He

  • 1The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan.

ACS Nano
|March 20, 2012
PubMed
Summary

We studied particle movement through tiny pores using a resistive pulse method. Low-aspect-ratio pores enhance particle capture and enable size discrimination, showing potential for DNA sequencing.

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Area of Science:

  • Nanotechnology
  • Biophysics
  • Electrical Engineering

Background:

  • Single-particle translocation is crucial for sensing applications.
  • Graphene nanopores offer unique electrical properties for biosensing.
  • Understanding pore geometry effects is key for optimizing translocation dynamics.

Purpose of the Study:

  • To investigate single-particle translocation through low-aspect-ratio silicon nitride pores mimicking graphene nanopores.
  • To analyze the contribution of access resistance to ion transport and particle translocation.
  • To demonstrate the potential of these nanopores for electrical sensing and particle discrimination.

Main Methods:

  • Resistive pulse measurements were used to study ion and particle transport.
  • Silicon nitride pores with a low thickness-to-diameter aspect ratio (0.05) were fabricated.

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Last Updated: May 24, 2026

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles
08:31

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

Published on: March 20, 2019

Monitoring Protein Adsorption with Solid-state Nanopores
08:51

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores
09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

  • Ionic conductance and particle capture rates were analyzed as a function of pore diameter and electric field.

    • Main Results:

    • Ionic conductance scaled linearly with pore diameter, dominated by access resistance.
    • Access resistance remained largely constant during particle translocation.
    • Enhanced particle capture rates were observed due to the extended electric field at the pore mouth.
    • Electrical discrimination of particles based on size was achieved.

    Conclusions:

    • Low-aspect-ratio nanopores, mimicking graphene structures, facilitate efficient particle capture and sensing.
    • The constant access resistance simplifies translocation analysis and enables size-based discrimination.
    • These findings highlight the potential of nucleotide-sized graphene nanopores for single-base identification via ionic current blockade detection.