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Quantifying gait abnormalities in persons with multiple sclerosis with minimal disability.

Jacob J Sosnoff1, Brian M Sandroff, Robert W Motl

  • 1Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, USA.

Gait & Posture
|March 20, 2012
PubMed
Summary

Subtle gait abnormalities in persons with multiple sclerosis (PwMS) are detectable with common technology. This study shows early gait changes in PwMS, even with minimal disability, using a pressure-sensitive walkway.

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Area of Science:

  • Neurology
  • Biomechanical Engineering
  • Rehabilitation Science

Background:

  • Persons with multiple sclerosis (PwMS) often exhibit gait abnormalities.
  • Previous studies utilized motion capture systems to detect these changes.
  • The feasibility of detecting early gait alterations with clinically accessible technology remains unclear.

Purpose of the Study:

  • To determine if spatiotemporal gait markers and variability metrics can differentiate PwMS with minimal disability from healthy controls.
  • To assess the utility of clinically feasible technology in identifying subtle gait deviations in early-stage multiple sclerosis.

Main Methods:

  • 43 PwMS with minimal disability and 43 healthy controls participated.
  • Participants completed four walking trials on a GAITRite pressure-sensitive pathway.

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  • Spatiotemporal gait parameters and variability metrics were analyzed.

    • Main Results:

    • PwMS exhibited slower walking speed, fewer, shorter, and wider steps compared to controls.
    • PwMS spent a greater percentage of the gait cycle in double support.
    • Increased variability in step time, single support duration, and step width was observed in PwMS.

    Conclusions:

    • Subtle, yet detectable, gait differences exist in PwMS even without apparent clinical impairment.
    • Clinically feasible technology can identify these early gait alterations.
    • These findings suggest the potential for earlier intervention targeting gait deviations in multiple sclerosis progression.