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Updated: May 24, 2026

Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
Warmth is analgesic in healthy newborns
Larry Gray1, Colleen W Lang, Stephen W Porges
1Developmental and Behavioral Pediatrics, Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA Brain-Body Center, Department of Psychiatry, University of Illinois at Chicago, The Psychiatric Institute (MC 912), Chicago, IL 60612, USA.
Providing natural warmth to newborn infants during vaccination significantly reduces pain behaviors. This nonpharmacologic method is as effective as pacifier suckling or sucrose taste for pain management in newborns.
Area of Science:
- Neonatal care
- Pain management
- Behavioral science
Background:
- Newborn infants experience pain during routine procedures like vaccinations.
- Nonpharmacologic methods are sought for pain reduction in neonates.
- Current standards include sucrose and pacifier use for analgesia.
Purpose of the Study:
- To evaluate the analgesic effect of warmth exposure in newborn infants undergoing vaccination.
- To compare warmth exposure with established methods like pacifier suckling and sucrose taste.
- To identify behavioral and nonpharmacologic strategies for reducing newborn pain.
Main Methods:
- Prospective randomized controlled trial involving 47 healthy full-term newborn infants.
- Infants were randomized into three groups: warmth exposure, pacifier suckling, or sucrose taste.
- Outcome measures included crying, grimacing, and heart rate changes before, during, and after vaccination.
Main Results:
- Infants receiving warmth exposure exhibited significantly less crying post-vaccination compared to pacifier or sucrose groups.
- Heart rate patterns corroborated the analgesic effect observed in the warmth group.
- No significant differences in core body temperature were noted between the study groups.
Conclusions:
- Natural warmth is an effective nonpharmacologic intervention for reducing pain in newborn infants during vaccination.
- Warmth exposure demonstrates comparable efficacy to sucrose and pacifier use in mitigating infant pain responses.
- Behavioral interventions like warmth provide a viable alternative for neonatal pain management.
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