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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...

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Management of severe acute alcoholic hepatitis in France: results of a national survey: R1.

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Updated: May 24, 2026

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

[Alcoholic hepatitis].

J-B Trabut1, V Thépot, P Sogni

  • 1Unité d'hépatologie, Inserm U1016, université Paris Descartes, hôpital Cochin Saint-Vincent-de-Paul, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. jean-baptiste.trabut@cch.aphp.fr

La Revue De Medecine Interne
|March 20, 2012
PubMed
Summary
This summary is machine-generated.

Severe alcoholic hepatitis, a critical form of alcoholic liver disease, requires prompt recognition. Corticosteroids improve survival in high-risk patients, while long-term outcomes depend on alcohol abstinence.

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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
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Area of Science:

  • Hepatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Alcoholic hepatitis is a severe manifestation of alcoholic liver disease (ALD).
  • Jaundice onset in patients with alcoholic cirrhosis often indicates alcoholic hepatitis.
  • Maddrey's discriminant function identifies patients with poor prognosis and high mortality risk.

Purpose of the Study:

  • To outline the diagnostic criteria and prognostic indicators for alcoholic hepatitis.
  • To review current and potential therapeutic strategies for severe alcoholic hepatitis.
  • To emphasize the critical role of alcohol abstinence in long-term patient outcomes.

Main Methods:

  • Literature review of studies on alcoholic hepatitis diagnosis and treatment.
  • Analysis of prognostic factors, including Maddrey's discriminant function.
  • Evaluation of treatment efficacy for corticosteroids and other therapies.

Main Results:

  • Maddrey's discriminant function > 32 predicts >50% 6-month mortality.
  • Corticosteroids are shown to increase survival in high-risk patients.
  • Further investigation is needed for pentoxifylline, N-acetyl-cysteine, and enteral nutrition.

Conclusions:

  • Corticosteroids are a recommended treatment for high-risk alcoholic hepatitis patients.
  • Liver transplantation is an option for select non-responsive patients.
  • Sustained alcohol abstinence is paramount for favorable long-term prognosis in alcoholic liver disease.