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Related Experiment Video

Updated: Aug 28, 2025

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

[Occult hepatitis B virus infection].

A Vallet-Pichard¹, S Pol¹

¹Unité d'hépatologie, hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris.

Virologie (Montrouge, France)

|September 22, 2022

Summary

Occult hepatitis B virus (HBV) infection, defined by HBV DNA without surface antigen (HBsAg), presents a diagnostic challenge. Its prevalence and clinical significance, particularly in immune-compromised individuals and liver disease progression, require further investigation.

Keywords:

hepatitis B hepatitis V virus

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Last Updated: Aug 28, 2025

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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

Area of Science:

Hepatology and Virology
Immunology
Molecular Biology

Context:

Occult hepatitis B virus (HBV) infection is characterized by the presence of HBV DNA in HBsAg-negative individuals.
Prevalence data for occult HBV infection are inconsistent across different populations.
The molecular basis involves persistent covalently closed-circular DNA (cccDNA) in cell nuclei.

Purpose:

To define occult hepatitis B virus (HBV) infection.
To explore the molecular basis and potential physiopathology of occult HBV infection.
To discuss the clinical relevance and implications of occult HBV infection.

Summary:

Occult HBV infection is identified by HBV DNA in patients negative for HBsAg via standard tests.
The persistence of HBV cccDNA in cell nuclei is the molecular basis for occult infection.
Host immune response, co-infections, and epigenetic factors may influence the occult status.

Impact:

Occult HBV infection poses risks for transmission through blood and organ donations.
It can lead to acute reactivation in immunosuppressed patients, especially those with isolated anti-HBc.
Potential roles in liver fibrosis progression and hepatocellular carcinoma development are under investigation.