Related Experiment Video
Updated: May 24, 2026
07:33
In vitro Organoid Culture of Primary Mouse Colon Tumors
Published on: May 17, 2013
[Epigenetics and colorectal cancer].
Pablo Menéndez1, Pedro Villarejo, David Padilla
1Servicio de Cirugía General y de Aparato Digestivo, Hospital Gutiérrez Ortega, Valdepeñas, Ciudad Real, España. pablomensan@hotmail.com
Cirugia Espanola
|March 20, 2012
Summary
Epigenetic modifications, including DNA methylation and histone alterations, significantly influence colorectal cancer development. These epigenetic changes are crucial in the origin and progression of this neoplastic disease.
Area of Science:
- Epigenetics
- Molecular Biology
- Oncology
Context:
- Epigenetic mechanisms regulate gene expression without altering DNA sequence.
- Chromatin structure is dynamically modified by processes like DNA methylation, histone modifications, and RNA changes.
- Colorectal cancer (CRC) is a significant global health concern with complex origins.
Purpose:
- To review the scientific literature on the association between epigenetics and colorectal cancer.
- To understand the role of epigenetic alterations in CRC pathogenesis.
Summary:
- A literature review of PubMed-published evidence was conducted.
- Epigenetic alterations, including DNA methylation and histone modifications, are implicated in the initiation and progression of colorectal cancer.
- These genetic modifications are significant in the origin of neoplastic disease.
Impact:
- Highlights the critical role of epigenetics in colorectal cancer.
- Provides insights into potential epigenetic targets for cancer therapy.
- Emphasizes the contribution of epigenetic changes to neoplastic disease development and progression.
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